Developmental Biology Program

The Thomas Vierbuchen Lab


Thomas Vierbuchen
Thomas S. Vierbuchen, PhD

The Vierbuchen laboratory seeks to elucidate fundamental mechanisms governing the production of the myriad neuronal cell types required to build functioning neural circuits. To model these dynamic developmental processes, we direct the differentiation of mouse and human pluripotent stem cells into specific neuronal cell types in a dish. This reductionist system allows us to recapitulate neural tube patterning and neuronal differentiation under controlled conditions and at a scale that makes it possible to use genetic screens, genomics, and systems genetics to characterize the underlying cell signaling and gene regulatory processes with unprecedented resolution. In the long term, we will apply these insights to better understand the complex genetic underpinnings of psychiatric and neurodegenerative disease.

The Thomas Vierbuchen Lab


Vierbuchen T*, Ling E*, Cowley C, Couch C, Harmin DA, Wang X, Roberts CW, Greenberg ME.  AP-1 transcription factors and the BAF complex mediate signal-dependent enhancer selection. Molecular Cell 68, 1067-1082 (2017)

Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof T, Wernig M.  Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463, 1035–1041 (2010)

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Thomas Vierbuchen

Thomas S. Vierbuchen, PhD

  • The Vierbuchen laboratory directs the differentiation of mouse and human pluripotent stem cells to characterize fundamental mechanisms of neuronal cell fate specification and function.
  • PhD, Stanford University School of Medicine
[email protected]
Email Address


Ann Kabuki Baako
Ann Kabuki Baako

Graduate Student, Weill Cornell Neuroscience program

Rachel Glenn
Rachel Glenn

Graduate Student, Weill Cornell BCMB program

Mohammed T. Islam
Mohammed T. Islam

Graduate Student, Gerstner Sloan Kettering Graduate School of Biomedical Sciences

Yuan Lin
Yuan Lin

Research Fellow

Daniel Medina-Cano
Daniel Medina-Cano

Research Fellow - NYSTEM Training Award at the CSCB

Kate Romero
Kate Romero

Administrative Assistant

Sarah Singer
Sarah Singer

Research Assistant

Lab Alumni
Emily Corrigan
Emily Corrigan

Current Position: Graduate Student, UCSF

Lab Affiliations


  • Josie Robertson Investigator (2018-2023)
  • David Hubel Award, Neurobiology Department, Harvard Medical School (2017)
  • HHMI Fellow of the Damon Runyon Cancer Research Foundation (2014-2018)
  • Harold M. Weintraub Graduate Student Award (2013)
  • Collegiate Inventors Competition (Finalist, 2010)

Lab News & Events

Upcoming event

Signaling, illuminated: Shining a Light on How Erk Signaling Dynamics Control Gene Expression and Cell Fate

Memorial Sloan Kettering Cancer Center
Zuckerman Research Center
417 East 68th Street
Room ZRC-105
New York, NY 10065

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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

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Thomas S. Vierbuchen discloses the following relationships and financial interests:

  • Neucyte Inc.
    Intellectual Property Rights; Ownership / Equity Interests

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