Scientists in SKI’s Structural Biology Program aim to understand biological processes at the levels of molecular mechanisms and three-dimensional structures. The experimental tools we employ range from cryo-electron microscopy and x-ray crystallography to super-resolution optical methods in studies that are complemented by biochemical, cell biology, and genetic approaches. We are focused on fundamental processes in biology with particular interests in understanding how these processes are dysregulated in cancer.
The work of our researchers covers diverse areas of biology including DNA-damage response, epigenetic modification of DNA and histones, RNA silencing, RNA processing, DNA and RNA structure, riboswitches, transcription, and growth-regulatory pathways. In addition, we investigate cell-surface receptors, vesicular transport and secretion, post-translational protein modification by ubiquitin and ubiquitin-like proteins, and membrane protein structure and function.
Dimitar B. Nikolov, PhD
The Nikolov laboratory focuses on the structural, biophysical, and biochemical characterization of the molecular mechanisms of cell-cell interactions and signal transduction in the nervous system.
Dinshaw Patel, PhD
The Patel laboratory studies the structural biology of macromolecular recognition, regulation and catalysis. Ongoing projects include structure-function studies of the CRISPR-Cas and cGAS-STING surveillance pathways, on the role of Structure Maintenance Chromosome complexes in mediating DNA double strand break repair, on the role of histone and DNA methylation in epigenetic regulation and on RNA-mediated processes ranging from riboswitches and ribozymes to those governing siRNA and piRNA pathways.
Nikola P. Pavletich, PhD
The Pavletich laboratory studies the structural biology of pathways that control cell growth and maintain the integrity of the genome.
Alexandros Pertsinidis, PhD
The Pertsinidis laboratory uses single-molecule approaches to understand gene transcription and the function of complex macromolecular machines inside live cells.
Collaborations & Resources
SKI offers a wide array of core facilities and other technologies, including a FEI Titan Krios cryo-electron microscope. Members of the Structural Biology Program derive particular benefit from close ties to the following: