Human Oncology & Pathogenesis Program
The Omar Abdel-Wahab Lab
Omar Abdel-Wahab is a Member in Human Oncology and Pathogenesis Program (HOPP), an Attending Physician on the Leukemia Service in the Department of Medicine at Memorial Sloan Kettering Cancer Center, and the Director of Memorial Sloan Kettering’s Center for Hematologic Malignancies. Dr. Abdel-Wahab’s research focuses on the role of genomic alterations in the pathogenesis of hematopoietic malignancies.
North K, Benbarche S, Liu B, Pangallo J, Chen S, Stahl M, Bewersdorf JP, Stanley RF, Erickson C, Cho H, Pineda JMB, Thomas JD, Polaski JT, Belleville AE, Gabel AM, Udy DB, Humbert O, Kiem HP, Abdel-Wahab O (co-corresponding), Bradley RK (co-corresponding). Synthetic introns enable splicing factor mutation-dependent targeting of cancer cells. Nat Biotechnol. 2022 Mar 3. doi: 10.1038/s41587-022-01224-2. Epub ahead of print.
Wang E, Mi X, Thompson MC, Montoya S, Notti RQ, Afaghani J, Durham BH, Penson A, Witkowski MT, Lu SX, Bourcier J, Hogg SJ, Erickson C, Cui D, Cho H, Singer M, Totiger TM, Chaudhry S, Geyer M, Alencar A, Linley AJ, Palomba ML, Coombs CC, Park JH, Zelenetz A, Roeker L, Rosendahl M, Tsai DE, Ebata K, Brandhuber B, Hyman DM, Aifantis I, Mato A, Taylor J, Abdel-Wahab O. Mechanisms of Resistance to Noncovalent Bruton’s Tyrosine Kinase Inhibitors. N Engl J Med. 2022 Feb 24;386(8):735-743. doi: 10.1056/NEJMoa2114110.
Lu SX, De Neef E, Thomas JD, Sabio E, Rousseau B, Gigoux M, Knorr DA, Greenbaum B, Elhanati Y, Hogg SJ, Chow A, Ghosh A, Xie A, Zamarin D, Cui D, Erickson C, Singer M, Cho H, Wang E, Lu B, Durham BH, Shah H, Chowell D, Gabel AM, Shen Y, Liu J, Jin J, Rhodes MC, Taylor RE, Molina H, Wolchok JD, Merghoub T, Diaz LA Jr, Abdel-Wahab O (co-corresponding; Lead Contact), Bradley RK (co-corresponding). Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell. 2021 Jun 18:S0092-8674(21)00690-5. doi: 10.1016/j.cell.2021.05.038. Epub ahead of print.
Inoue D, Polaski JT, Taylor J, Castel P, Chen S, Kobayashi S, Hogg SJ, Hayashi Y, Pineda JMB, El Marabti E, Erickson C, Knorr K, Fukumoto M, Yamazaki H, Tanaka A, Fukui C, Lu SX, Durham BH, Liu B, Wang E, Mehta S, Zakheim D, Garippa R, Penson A, Chew GL, McCormick F, Bradley RK, Abdel-Wahab O. Minor intron retention drives clonal hematopoietic disorders and diverse cancer predisposition. Nat Genet. 2021 Apr 12. doi: 10.1038/s41588-021-00828-9. Epub ahead of print.
Taylor J, Donoghue MT, Ho C, Petrova-Drus K, Al-Ahmadie HA, Funt SA, Zhang Y, Aypar U, Rao P, Chavan SS, Haddadin M, Tamari R, Giralt S, Tallman MS, Rampal RK, Baez P, Kappagantula R, Kosuri S, Dogan A, Tickoo SK, Reuter VE, Bosl GJ, Iacobuzio-Donahue CA, Solit DB, Taylor BS, Feldman DR, Abdel-Wahab O. Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor. J Clin Invest. 2020 Dec 1;130(12):6668-6676. doi: 10.1172/JCI139682. PMCID: PMC7685753.
Omar Abdel-Wahab, MD
Edward P. Evans Chair in MDS, Director, MSK Center for Hematologic Malignancies, Member, Human Oncology and Pathogenesis Program & Leukemia Service
- Physician-scientist Omar Abdel-Wahab studies the functional genomics of hematopoietic malignancies.
- MD, Duke University School of Medicine
- Josie Robertson Investigator (2012-2017)
- Seldin-Smith Award for Pioneering Research, American Society of Clinical Investigation
- Pershing Square Sohn Prize for Young Investigators in Cancer Research
- Leukemia & Lymphoma Society Clinical Scholar Award
- Joanne Levy Memorial Award for Outstanding Achievement, American Society of Hematology
- V Scholar Award, V Foundation
- Junior Faculty Scholar Award, American Society of Hematology (ASH)
- Damon Runyon Clinical Investigator Award
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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.
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Omar Abdel-Wahab discloses the following relationships and financial interests:
Harmonic Discovery Inc.
Ownership / Equity Interests
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This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.