Cancer Biology & Genetics Program

The Joan Massagué Lab


Joan Massagué, PhD
Joan Massagué, PhD
Member, Cancer Biology & Genetics Program; Marie-Josée and Henry R. Kravis Foundation Chair; Director, Sloan Kettering Institute

We are interested in metastasis, the cause of 90% of cancer deaths. The lab investigates metastatic stem cells and their stromal niches. The role of immune regulatory and regenerative signals, particularly TGF-β, is of interest. General as well as organ-specific mediators of metastasis are under investigation. We are defining the phenotypic plasticity and evolution of metastatic cell populations from dormancy to outbreak, identifying drug targets, and enabling clinical trials to treat metastasis.

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Inside My Lab: Joan Massagué

Go inside the lab of Joan Massagué, director of the Sloan Kettering Institute.
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Laughney, A.M., Hu, J., Campbell, N.R., Bakhoum, S.F.,Setty, M., Lavallée, V.-P., Xie, Y., Masilonis, I., Carr, A.J., Allaj, V., Mattar, M., Rekhtman, N., Xavier, J., Mazutis, L., Poirier, J.T., Rudin, C.M., Pe’er, D. and Massagué, J. Regenerative lineages and immune-mediated pruning in lung cancer metastasis. Nature Medicine 26, 259-269 (2020)

Su, J., M. Morgani, S.M., David, C.J., Wang, Q., Emrah Er, E.E., Huang, Y.-H., Basnet, H., Zou, Y., Shu, W., Hendrickson, R.C., Soni, R.K., Hadjantonakis, A.-K. and Massagué, J. TGF-β orchestrates fibrogenic and developmental EMTs via RAS effector RREB1. Nature 577, 566–571 (2020)

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Joan Massagué, PhD

Joan Massagué, PhD

Member, Cancer Biology & Genetics Program; Marie-Josée and Henry R. Kravis Foundation Chair; Director, Sloan Kettering Institute

  • Joan Massagué studies the control of stem cell growth and phenotype in tumor progression, metastasis, and response to therapy.
  • PhD, University of Barcelona
[email protected]
Email Address
Office Phone


Lan He
Lan He

Senior Research Assistant

Jing Hu, PhD
Jing Hu

Sr. Research Scientist

Yasemin Kaygusuz, BS
Yasemin Kaygusuz

GSK, Graduate Student

Zhenghan Wang
Zhenghan Wang

Sr. Research Scientist

Derniele David
Derniele David

SKI, Admin. Assistant II

Siting Gan
Siting Gan

Postdoctoral Researcher

Gabriela N. Johnson
Gabriela N. Johnson

Research Assistant

Kenta Kawasaki
Kenta Kawasaki

Research Fellow

Jun Ho Lee
Jun Ho Lee

Research Scholar

Jin Suk Park
Jin Suk Park

Research Scholar

Constantina (Dina) Rodriguez
Constantina (Dina) Rodriguez

Sr. Executive Assistant

Sayyed Hamed Shahoei
Sayyed Hamed Shahoei

Research Scholar

Elena Spina
Elena Spina

Research Associate

Vijay Yarlagadda
Dig Vijay Yarlagadda

Tri-I PhD, CBM, Graduate Student

Lab Alumni
Saloni Agrawal
Saloni Agrawal

Medical Student Mount Sinai

Harihar Basnet
Harihar Basnet

Assistant Professor, Tsinghua University, Beijing

Ekrem Emrah Er
Ekrem Emrah Er

Assistant Professor- University of Illinois, Chicago

Karuna Ganesh, MD, PhD
Karuna Ganesh

Assistant Member, Molecular Pharmacology Program, SKI; Department of Medicine

Jessica Hampton
Jessica Hampton

Medical Student, Stanford, CA

Yun-Han Huang
Yun-Han Huang

Internal Medicine Resident at Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Weiping Shu
Weiping Shu

Senior Research Assistant

Jie Su
Jie Su

Group Leader, Accutar Biotech

Lin Tian, PhD
Lin Tian

Research Investigator @ Biomarker Discovery, Beijing, China

Qiong Wang
Qiong Wang

Assistant Professor, Shanghai Jiao Tong University, China

Swarnali Acharyya

Assistant Professor of Pathology & Cell Biology, Columbia University

Claudio Alarcón, PhD
Claudio Alarcón

Assistant Professor, Yale University

Janet Andres

Supervisory Patent Examiner, US Patent & Trademark Office

Joaquin Arribas

Director of Preclinal Research, Vall d'Hebron Institute of Oncology, BCN

Liliana Attisano

Chair, Biochemistry, University of Toronto

Anna Bassols

Director Veterinary Clinical Biochemistry, University of Barcelona

Stacy Blain

Associate Professor, SUNY Downstate Medical Center

Adrienne Boire, MD, PhD
Adrienne Boire

Neuro-Oncologist / MSK HOPP Program

Paula Bos

Assistant Professor, Virginia Commonwealth University

Marcus Bosenberg

Associate Professor, Yale University

Frederick T. Boyd

Volunteer and Research Assistant, University of Arizona

Julia Calonge

Counselor of Citizens in the District, Barcelona Spain

Juan Carcamo

Principle Scientist, Eli Lilly and Company, New York

Nadia Cervoni

EVP, Director of Medical and Scientific Affairs at DDB Health

Sela Cheifetz

Professor, University of Toronta

Chang-Rung Chen

Senior Director, ArQule Inc.

Qing Chen, MD, PhD
Qing Chen

Assistant Professor, The Wistar Institute, Philadelphia, PA

Ye-Guang Chen

Professor, Tsinghua University, Beijing

Anne Chiang

Associate Professor; Chief Integration Officer and Deputy Chief Medical Officer, Smilow Cancer Network, Yale

Supratik Das

Staff Scientist, Albert Einstein College of Medicine, NY

Charles David
Charles David

Assistant Professor, Tsinghua University, Beijing, China

Jacqueline Doody

Consultant in Immuno-oncology

Sheng Gao

Associate Director, Clinical Biomarkers, Bristol-Myers Squibb

Diane George

Member, Pediatric Oncology & Hematology, Columbia University

Roger Gomis

Member, Institut de Recerca Biomedica, Barcelona

Bailey Griscom
Bailey Griscom

Senior Clinical Research Associate at Veracyte, Inc.

Assistant Professor, U. North Carolina
Gaorav Gupta

Assistant Professor, U. North Carolina

Akiko Hata

Professor, Cardiovascular Research Institute, UCSF

Wei He

Chief Scientific Officer at Accutar Biotec

Jyrki Heino

Professor & Chair, Dept Biochemistry, U. Turku, Finland

Antonio Iavarone

Professor of Pathology, Columbia University

Ronald A. Ignotz

Assistant Professor, University of Massachusetts Medical School

Leni Jacob

Scientist II, Biology at BluePrint Medicines

Lata Jayaraman

Head, Tumor Immunotherapy, Seres Therapeutics

Xin Jin

Assistant Professor, Westlake University, China

Yibin Kang

Professor of Molecular Biology, Princeton University

Mi Young Kim

Assistant Professor, KAIST, Korea

Marcus Kretzschmar
Marcus Kretzschmar

Head of Intellectual Property, Molecular Partners AG; Switzerland

Marikki Laiho

Professor of Radiation Oncol, Johns Hopkins School of Medicine

George Lampe
George Lampe

Graduate Student @ Columbia University

Ashley M. Laughney
Ashley M. Laughney

Assistant Professor, Cornell University

Hong-Van Le

Patent Attorney, Novartis

Derek Lee
Derek Lee

Research Technician

Mong-Hong Lee

Assoc. Professor of Mol. Cell. Oncology, MD Anderson Cancer Center

Liangji Li
Liangji Li

Research Scholar

Fang Liu

Associate Member, Rutgers Cancer Institute, NJ

Roger Lo

Professor, Baylor College of Medicine, Houston

Fernando Lopez-Casillas

Professor, Universidad Nacional Autonoma de Mexico

Alejandro Lopez-Soto, PhD
Alejandro Lopez-Soto

University of Oviedo, Spain

Yan Luo

Senior Medical Director at AbbVie, Chicago

Danilo Reynaldo Macalinao
Danilo G. Macalinao

Student, St. Joseph's Seminary, Washington

Srinivas Malladi

Assistant Professor of Pathology, UT Southwestern Med, Dallas

Dylan Manuele
Dylan Manuele

Research Technician

Dina Marenstein

EVP, Director of Medical & Scientific Services at Chameleon Communications International

Andy Minn

Assistant Professor of Radiation Oncology, U. Pennsylvania

Cristina Nadal

Biocat Director of Healthcare Programs

Don Nguyen

Associate Professor of Pathology, Yale University

Anna Obenauf

Group Leader, (IMP) Institute of Molecular Pathology, Austria

Masahiko Ohtsuki

Corporate Officer, VP Business Dev.& Licensing, Daiichi Sankyo Co. Ltd, Tokyo

Thordur Oskarsson

Group Leader, German Cancer Research Center

David Padua

Assistant Professor, UCLA

Atanasio Pandiella

Professor, CSIC, Salamanca

Boris Pasche

Director, Wake Forest School of Medicine

Lila Peters
Lila Peters

GSK, Graduate Student

Kornelia Polyak

Professor, Dana-Farber Cancer Institute, Harvard University

Celio Pouponnot

Research Director, CNRS and Institute Curie, Paris

David Ralph

Management, Integrated Bioscience Solutions, LLC

Inga Reynisdottir

Principal Investigator, Landspitali University Hospital; University of Iceland

Lars Rönnstrand

Professor of Cancer Research, Lund University, Sweden

Gopal Sapkota

Program Leader, University of Dundee, UK

Joan Seoane

Research Director, Vall Hebron Institute of Oncology, Barcelona

Jason Shieh
Jason Shieh

Student, Stony Brook University

Peter Siegel

Assoc. Professor of Biochemistry & Medicine, McGill University

Carmella Stephens

Partner at Carter, DeLuca, Farrell & Schmidt, LLP

Sohail Tavazoie

Professor, Rockefeller University, New York

Joaquin Teixido

Professor, Consejo Superior de Investigactiones Cientificas, Madrid

Dori Thomas

Staff Scientist, Hoffmann-La Roche Inc.

Luis Ulloa

Associate Professor in Anesthesiology, Duke University

Manuel Valiente-Cortes

Group Leader, CNIO, Madrid

Sakari Vanharanta

Program Leader, Medical Research Council (MRC), U. Cambridge

Francesc Ventura

Professor, University of Barcelona School of Medicine

Denis Vivien

Professor, Universite de Caen, France

Qiongqing Wang

Staff Scientist, Hoffman-La Roche, Inc.

Beverly Warner

Genetic Counselor, Peter MacCallum Cancer Institute, Australia

Frances M.B. Weis
Frances M.B. Weis

Associate Laboratory Member, Research Facilities @ MSKCC

Rotraud Wieser

Associate Professor of Medicine, University of Vienna, Austria

David Wotton

Assoc. Professor of Biochemistry, University of Virginia

Jeffrey L. Wrana

Senior Investigator, Lunenfeld Research Institute, U. Toronto

Qiaoran (Karen) Xi

Assistant Professor, Tsinghua University, Beijing

Lan Xu

Director, Biology at Foghorn Therapeutics

Alexia Zaromytidou

Chief Editor, Nature Cancer @ Nature Publishing

Alejandro Zentella

Professor, Universidad Nacional Autonoma de Mexico

Xiang (Shawn) Zhang

Professor, Baylor College of Medicine, Houston

Yilong Zou

Assistant Professor, Westlake University, China

Lab Affiliations


  • Director, Sloan Kettering Institute (2014–)
  • HHMI Scientific Review Board (2014–)
  • HHMI Investigator (1990-2013)
  • Fellow, American Association for Cancer Research (AACR) Academy (2016)
  • Pezcoller Foundation-AACR International Award for Cancer Research (2016)
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  • Charles Rodolphe Brupbacher Prize for Cancer Research (2015)
  • National Prize for Research in Biology, Spain (2014)
  • American Italian Cancer Foundation Price (2013)
  • Prize in Cancer Research, Robert J. and Claire Pasarow Foundation (2011)
  • Frontiers Prize in Biomedicine, BBVA Foundation (2008)
  • Vilcek Prize, Vilcek Foundation (2006)
  • Member, Institute of Medicine (2006)
  • Award in Science and Technology, Prince Asturius Foundation (2004)
  • Member, National Academy of Sciences (2000)
  • Member, American Academy of Arts and Sciences (1999)
  • Investigator, Howard Hughes Medical Institute (1990)
  • Elucidation of the TGF-beta pathway

Lab News & Events

Upcoming event

Specific FAM83 Proteins Direct CK1 Family of Kinases to Control WNT Signaling and Mitosis

Memorial Sloan Kettering Cancer Center
Rockefeller Research Laboratories
430 East 67th Street
Room RRL-104
New York, NY 10065


Team Recognitions

  • Welcome to the Massague Lab : Elena Spina arrived in August from University of Calabria.
  • Welcome to the Massague Lab: Kenta Kawasaki arrived in October from Keio University School of Medicine.
  • Welcome to the Massague Lab: Dylan Manuele arrived in June from the University of Rochester.
  • Congratulations: Our first in person lab meeting for 2021!
  • The Massague Lab celebrates the arrival of Zhenghan Wang’s daughter Everly!
  • Farewell: Weiping Shu has retired from the Massague lab after many years of fantastic service as a senior research technician. Thank you Weiping for all your contributions!
  • Congratulations: Harihar Basnet who departed in February as Assistant professor in the Department of Basic Medical Sciences at Tsinghua University
  • Welcome: Sayyed Hamed Shahoei who joined in November from University of Illinois at Urbana-Champaign
  • Congratulations : Lin Tian who departed in November as research investigator at the division of Biomarker Discovery, Shanghai China
  • Welcome to the Massague Lab: Lila Peters arrived in July from the University of Michigan
  • Congratulations: George Lampe departed in July to Graduate School at Columbia University.
  • Welcome to the Massague Lab: Jun Ho Lee joined in May from UNIST, Uslan, Republic of Korea
  • Welcome to the Massague Lab: Jin Suk Park joined in March from University of Texas Southwestern Medical Center, Dallas
Annual Home Gathering

Dr. Massague invited the postdocs to his home for an annual gathering.

Happy Birthday Gabi

In October 2021, A small birthday celebration was held for Gabi.

August : Happy Hour Cruise

The Massague Lab had the pleasure to attend a summer happy hour cruise! It was a wonderful time!

Congratulations: Our first in person lab meeting for 2021!

The Massague Lab attending their Friday Lab Meetings!

Congratulations : The Massague Lab celebrates the arrival of Zhenghan Wang’s daughter Everly!

The Massague Lab celebrates the arrival of Zhenghan Wang’s daughter Everly!

Happy Birthday Joan

Happy Birthday Joan !

Happy Birthday Joan :  Post Doc Jin Suk Park playing the clarinet for Dr. Massague’s Birthday!

Happy Birthday Joan: Post Doc Jin Suk Park playing the clarinet for Joan’s Birthday!

Farewell: Weiping Shu

Farewell: Weiping Shu has retired from the Massague lab after many years of fantastic service as a senior research technician. Thank you Weiping for all your contributions!

The Massague Lab at a farewell dinner

In June 2019, we bid a farewell to one of our Research Techs, Jessica Hampton. Jessica will be leaving to attend Med school at Stanford University. The Massague Lab wishes her well in all of her future endeavors

Scientific image

March 2019 - Paper Published. During metastasis, cancer cells spread to distant organs where they divide to form microscopic clusters, or micrometastases, that can grow into new tumors. Identification of genes activated in micrometastases can reveal therapeutic targets that can kill cancer cells before they grow into larger tumors that are harder to treat.

Happy Birthday Joan

The Massague Lab came together to celebrate Dr. Massague's Birthday

Happy Birthday Joan

The Massague Lab came together to wish Dr. Massague a Happy Birthday!

Holiday Party

The Massague Lab at Holiday Party

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Doctors and faculty members often work with pharmaceutical, device, biotechnology, and life sciences companies, and other organizations outside of MSK, to find safe and effective cancer treatments, to improve patient care, and to educate the health care community.

MSK requires doctors and faculty members to report (“disclose”) the relationships and financial interests they have with external entities. As a commitment to transparency with our community, we make that information available to the public.

Joan Massagué discloses the following relationships and financial interests:

  • Institute Research Biomedicine, Barcelona, Spain
    Provision of Services
  • Scholar Rock
    Ownership / Equity Interests

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This page and data include information for a specific MSK annual disclosure period (January 1, 2021 through disclosure submission in spring 2022). This data reflects interests that may or may not still exist. This data is updated annually.

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