Brian J. Joseph, PhD

Postdoctoral fellow at Columbia University, New York, NY

Brian J. Joseph, PhD

Postdoctoral fellow at Columbia University, New York, NY
Pictured: Brian J. Joseph


Cryptic Splice Sites are Agents of Order and Chaos During pre-mRNA Splicing (2021)

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BS, Massachusetts Institute of Technology


  • 2018 GSK Chairman’s Prize Award


Joseph B, Lai EC. (2021) The Exon Junction Complex and intron removal prevent re-splicing of mRNA. PLos Genet. 17.

Kan L, Ott S, Joseph B, Park ES, Dai W, Kleiner RE, Claridge-Chang A, Lai EC. (2021) A neural m6A/Ythdf pathway is required for learning and memory in Drosophila. Nat Commun.12.

Wei L, Lee S, Majumdar S, Zhang B, Sanfilippo P, Joseph B, Miura P, Soller M, Lai EC. (2020) Overlapping Activities of ELAV/Hu Family RNA Binding Proteins Specify the Extended Neuronal 3’ UTR Landscape in Drosophila. Mol Cell 80. 140-155

Joseph B, Kondo S, Lai EC. (2018) Short cryptic exons mediate recursive splicing in Drosophila. Nat Struct Ml Biol. 25, 365-371.

Kavaler J, Duan H, Aradhya R, de Navas LF, Joseph B, Shklyar B, Lai EC. (2018) miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs. J Cell Biol 217, 571-583. PMCID:PMC5800810

Kan L, Grozhik AV, Vedanayagam J, Patil DP, Pang N, Lim KS, Huang YC, Joseph B, Lin CJ, Despic V, Guo J, Yan D, Kondo S, Deng WM, Dedon PC, Jaffrey SR, Lai EC. (2017) The m6A pathway facilitates sex determination in Drosophila. Nat Commun. 8, 15737. PMCID: PMC5500889

Westholm JO, Miura P, Olson S, Shenker S, Joseph B, Sanfilippo P, Celniker SE, Graveley BR, Lai EC. (2014) Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation. Cell Rep., 9, 1966-80. PMCID: PMC4279448.

Zhang Y1, Pelet JM, Heller DA, Dong Y, Chen D, Gu Z, Joseph BJ, Wallas J, Anderson DG.  (2013) Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery. Adv Mater., 25, 4641-5. PMCID: PMC3898629.

Schroeder A, Goldberg MS, Kastrup C, Wang Y, Jiang S, Joseph BJ, Levins CG, Kannan ST, Langer R, Anderson DG. (2012) Remotely Activated Protein-Producing Nanoparticles. Nano Lett., 12, 2685-9. PMCID: PMC3388722.